Granuloma-in-follicles in pediatric Crohn’s disease
نویسندگان
چکیده
Methods 17 pCD patients with granulomas were genotyped for CD-associated mutations or polymorphisms in NOD2 and autophagy-related genes ATG1 and ATG16L1. Granulomas were found in intestinal biopsies of 22 out of 83 endoscopic and 9 out of 12 surgical procedures. Of each procedure we selected one biopsy per organ to study the cellular composition and cytokine profile of granulomas. We stained 43 paraffin-embedded, formalin-fixed pCD biopsies with hematoxylin&eosin and monoclonal antibodies targeting leukocyte markers (HLA-DR, CD68, CD4, CD8, CD20, IL23R) and cytokines (TNFa, IFNg, IL6, IL10, IL17, TGFb) (Figure 1) Morphology and immunohistochemistry were scored semi-quantitatively.
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